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The large open reservoirs and hanging-drop openings, combined with continuous recirculation of the medium, prevent the formation of potentially hypoxic regions in the small microchannels, an issue that may occur in plastic platforms but is rarely experienced with PDMS-based systems 54

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Targeting Glucagon-like Peptide-1 Receptor (GLP-1R) One of the first GLP-1R agonists approved for use was YETTA (also written as Byetta) developed by Amylin Pharmaceuticals and Eli Lilly and Co

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